EP0138385A2
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EP
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Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressings comprising same
Assignee: University of Illinois System
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Filing: 1984-09-13
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Granted: —
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Expires: 2004-09-13
Abstract
Abstract Hydrophilic biopolymeric copolyelectrolytes comprising (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from the group consisting of collagen and a glucosaminoglycan. Hydrogel membranes formed from the copolyelectrolytes are useful as biodegradable dressings for denuded tissue wound sites.
Inventors
- 👤 Abe Widra
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:46
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L26/00; A61L26/0009; A61L26/0023; A61L26/0028; A61L26/0033; A61L27/00; A61L27/28; A61L27/34; C; C08; C08H; C08H1/00; C08H1/06; C08L; C08L5/00; C08L5/08; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
70 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from a glucosaminoglycan and collagen, the weight ratio of said anionic protein polyelectrolyte component to said cationic biopolymer polyelectrolyte component lying within the range of from 0.001:1 to 16:1 but outside the range of from 1:1 to 10:1.
Claim 2
Dependent Claim
70 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from a glucosaminoglycan and collagen, the weight ratio of said anionic protein polyelectrolyte component to said cationic biopolymer polyelectrolyte component lying within the range of from 0.001:1 to 16:1 but outside the range of from 1:1 to 10:1.
Claim 3
Dependent Claim
22 words
The copolyelectrolyte of Claim 1, comprising an integral mixture of said anionic protein . polyelectrolyte component and said cationic protein polyelectrolyte component.
Claim 4
Dependent Claim
45 words
The copolyelectrolyte of Claim 1, comprising one or more layers of said anionic protein polyelectrolyte component, which anionic layers may be the same or different, alternated with one or more layers of cationic protein polyelectrolyte component, which cationic layers may be the same or different.
Claim 5
Dependent Claim
14 words
The'copolyelectrolyte of any preceding claim, wherein said anionic protein polyelectrolyte component is ammonium keratinate.
Claim 6
Dependent Claim
15 words
The copolyelectrolyte of Claim 4, wherein the keratin moiety of said ammonium keratinate is alpha-keratose.
Claim 7
Dependent Claim
11 words
The copolyelectrolyte of any preceding claim, wherein said glucosaminoglycan is chitosan.
Claim 8
Dependent Claim
16 words
The copolyelectrolyte of any preceding claim, wherein said cationic biopolymer polyelectrolyte component is a biopolymer carboxylate.
Claim 9
Dependent Claim
13 words
The copolyelectrolyte of Claim 7, wherein said biopolymer carboxylate is a biopolymer acetate.
Claim 10
Dependent Claim
31 words
The copolyelectrolyte of any preceding claim, wherein the weight ratio of said anionic protein polyelectrolyte component to said cationic biopolymer polyelectrolyte component is within the range of from 0.001:1 to 1:1.
Claim 11
Dependent Claim
37 words
The copolyelectrolyte of any preceding claim, wherein the biopolymer moiety of said cationic biopolymer polyelectrolyte component is a mixture of chitosan and collagen in a chitosan to collagen weight ratio of from about 0.5:1 to about 13:1.
Claim 12
Dependent Claim
50 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from a glucosaminoglycan and collagen, the weight ratio of said glucosaminoglycan to said collagen being within the range from more than 2:1 to 13:1.
Claim 13
Dependent Claim
50 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from a glucosaminoglycan and collagen, the weight ratio of said glucosaminoglycan to said collagen being within the range from more than 2:1 to 13:1.
Claim 14
Dependent Claim
23 words
The copolyelectrolyte of Claim 11, wherein said weight ratio of said glucosaminoglycan to said collagen is within the range from 3:1 to 10:1.
Claim 15
Dependent Claim
21 words
A composition comprising the copolyelectrolyte of any preceding claim, and a flexibility- and/or adhesion-enhancing amount of a non-toxic plasticizer or softener.
Claim 16
Dependent Claim
12 words
The composition of Claim 13, wherein said plasticizer or softener is glycerol.
Claim 17
Dependent Claim
14 words
A composition comprising the copolyelectrolyte of any one of Claims 1-12, and an antibiotic.
Claim 18
Dependent Claim
14 words
A hydrogel comprising the copolyelectrolyte of any one of Claims 1-12 in hydrated form.
Claim 19
Dependent Claim
24 words
A membrane comprising at least one layer of the hydrogel of Claim 16, said membrane having a thickness of at least about 1 mil.
Claim 20
Dependent Claim
26 words
The membrane of Claim 17, wherein both cationic chitosan and cationic collagen are present either in the same hydrogel layer or in two separate hydrogel layers.
Claim 21
Dependent Claim
18 words
A biodegradable dressing for burn wounds and other denuded tissue wound sites, comprising the membrane of Claim 17.
Claim 22
Dependent Claim
20 words
The dressing of Claim 19, wherein said membrane includes a flexibility- and/or adhesion-enhancing amount of a non-toxic plasticizer or softener.
Claim 23
Dependent Claim
12 words
The dressing of Claim 20, wherein said plasticizer or softener is glycerol.
Claim 24
Dependent Claim
14 words
The dressing of any one of Claims 19-21, wherein said membrane includes an antibiotic.
Claim 25
Dependent Claim
15 words
A biodegradable lining for surgical prostheses, comprising the copolyelectrolyte of any one of Claims 1-18.
References Cited (Backward Citations)
No citation records indexed.
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