EP0130577A2
Expired / Lapsed
EP
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Method for producing liposomes
Assignee: Daiichi Pharmaceutical Co Ltd
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Filing: 1984-06-28
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Granted: —
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Expires: 2004-06-28
Abstract
Abstract A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile solvent and, then, dispersing the mixture in an aqueous medium. The pharmaceutically acceptable liposome preparation as a drug delivery system can thus be produced with efficiency on an industrial scale.
Inventors
- 👤 Hiroshi Kikuchi
- 👤 Hitoshi Yamauchi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:00
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
26 words
A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile organic solvent and dispersing the resulting mixture in an aqueous medium.
Claim 2
Independent Claim
26 words
A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile organic solvent and dispersing the resulting mixture in an aqueous medium.
Claim 3
Dependent Claim
34 words
A method for producing liposomes as claimed in Claim 1, wherein said water-soluble non-volatile organic solvent is at least one member selected from the group consisting of polyhydric alcohols, glycerin esters and benzyl alcohol.
Claim 4
Dependent Claim
57 words
A method for producing liposomes as claimed in Claim 1 or 2, wherein said water-soluble non-volatile organic solvent is used in a proportion of about 1 to about 100 parts by weight per part by weight of said membrane components and about 0.001 to about 2 parts by weight per part by weight of said aqueous medium.
Claim 5
Dependent Claim
27 words
A method for producing liposomes as claimed in Claim 1, wherein said membrane components are selected from the group consisting of phospholipids, glycolipids and dialkyl-type synthetic surfactants.
Claim 6
Dependent Claim
26 words
A method for producing liposomes as claimed in Claim 4, wherein said membrane components further contain at least one of membrane stabilizers, charge modifiers and antioxidants.
Claim 7
Dependent Claim
36 words
A method for producing liposomes as claimed in Claim 5, wherein said membrane stabilizers are used in a proportion of about 0 to about 2 parts by weight per part by weight of the membrane components.
Claim 8
Dependent Claim
33 words
A method for producing liposomes as claimed in Claim 5, wherein said charge modifiers are used in a proportion of about 0.1 part by weight per part by weight of the membrane components.
Claim 9
Dependent Claim
31 words
A method for producing liposomes as claimed in Claim 1 or 4, wherein said membrane components are mixed with said water-soluble non-volatile organic solvent at a temperature of 70 to 90°C.
Claim 10
Dependent Claim
19 words
A method for producing liposomes as claimed in Claim 5 or 6, wherein said membrane stabilizer is a sterol.
Claim 11
Dependent Claim
33 words
A method of producing liposomes as claimed in Claim 9, wherein said sterol is mixed with said water-soluble non-volatile organic solvent at a temperature not lower than the melting point of the sterol.
Claim 12
Independent Claim
35 words
A method for producing a liposome preparation which comprises mixing liposome membrane components with a water-soluble non-volatile organic solvent, dispersing the resulting mixture in an aqueous medium, and encapsulating a drug into the resulting liposomes.
Claim 13
Independent Claim
35 words
A method for producing a liposome preparation which comprises mixing liposome membrane components with a water-soluble non-volatile organic solvent, dispersing the resulting mixture in an aqueous medium, and encapsulating a drug into the resulting liposomes.
Claim 14
Dependent Claim
82 words
A method for producing a liposome preparation as claimed in Claim 11, wherein a water-soluble drug is added to the aqueous medium and said water-soluble non-volatile organic solvent containing said membrane component is mixed with said aqueous medium, or wherein a lipid-soluble drug is added to said water-soluble non-volatile solvent and is mixed with said aqueous medium, or wherein a drug miscible with said water-soluble organic solvent is added to said water-soluble non-volatile organic solvent and is mixed with said aqueous medium.
Claim 15
Dependent Claim
68 words
Liposomes obtainable by mixing liposome membrane components selected from the group consisting of phospholipids, glycolipids and dialkyl-type synthetic surfactants, optionally containing at least one of membrane stabilizers, charge modifiers and antioxidants, with a water-soluble non-volatile organic solvent selected from the group consisting of polyhydric alcohols, glycerin esters and benzyl alcohol and dispersing the resulting mixture in an aqueous medium and optionally encapsulating a drug into the resulting liposomes.
Claim 16
Dependent Claim
68 words
Liposomes obtainable by mixing liposome membrane components selected from the group consisting of phospholipids, glycolipids and dialkyl-type synthetic surfactants, optionally containing at least one of membrane stabilizers, charge modifiers and antioxidants, with a water-soluble non-volatile organic solvent selected from the group consisting of polyhydric alcohols, glycerin esters and benzyl alcohol and dispersing the resulting mixture in an aqueous medium and optionally encapsulating a drug into the resulting liposomes.
References Cited (Backward Citations)
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