EP0128041A2
Expired / Lapsed
EP
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Polypeptides exhibiting skeletal growth factor activity
Assignee: Individual
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Filing: 1984-06-05
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Granted: —
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Expires: 2004-06-05
Abstract
Abstract Polypeptide compositions are provided which when introduced into a host enhance bone growth, as well as alkaline and acid phosphatase levels in vivo. The polypeptides may also be used in diagnostics for preparation of reagents or antibodies. The polypeptides range in molecular weight from about 10,000 to about 200,000dal.
Inventors
- 👤 David Jeston Baylink
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 03:21
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
22 words
A vertebrate skeletal growth factor of from about 100,000 to 200,000dal or fragment thereof, capable of stimulating a proliferation of bone cells.
Claim 2
Dependent Claim
22 words
A vertebrate skeletal growth factor of from about 100,000 to 200,000dal or fragment thereof, capable of stimulating a proliferation of bone cells.
Claim 3
Dependent Claim
24 words
A skeletal growth factor according to Claim 1, wherein said vertebrate is mammal, and said growth factor is of from about 150,000 to 200,000dal.
Claim 4
Dependent Claim
25 words
A skeletal growth factor according to Claim 1, wherein said mammal is human and said skeletal growth factor is of from about 150,000 to 200,000dal.
Claim 5
Dependent Claim
22 words
A skeletal growth factor according to Claim 1, wherein said skeletal growth factor is a fragment of from about 10,000 to 20,000dal.
Claim 6
Dependent Claim
13 words
A skeletal growth factor according to Claim 1, wherein said vertebrate is human.
Claim 7
Dependent Claim
13 words
A skeletal growth factor according to Claim 1, wherein said vertebrate is bovine.
Claim 8
Dependent Claim
13 words
A skeletal growth factor according to Claim 1, wherein said vertebrate is chicken.
Claim 9
Dependent Claim
27 words
A method for enhancing the proliferation of bone, said method comprising: contacting bone cells with an effective amount of a skeletal growth factor according to Claim 1.
Claim 10
Dependent Claim
11 words
A method according to Claim 8, wherein said vertebrate is human.
Claim 11
Dependent Claim
14 words
Antibodies capable of binding to a vertebrate skeletal growth factor according to Claim 1.
Claim 12
Dependent Claim
15 words
Antibodies according to Claim 10, conjugated with a label capable of providing a detectable signal.
Claim 13
Dependent Claim
49 words
A method for determining the presence of a vertebrate skeletal growth factor according to Claim 1, which comprises: combining a sample suspected of containing said skeletal growth factor with an antibody according to Claim 10, and determining the occurrence of binding of said antibody to said skeletal growth factor.
References Cited (Backward Citations)
No citation records indexed.
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