EP0108912A2
Expired / Lapsed
EP
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Poly(glycolic acid)/poly(alkylene glycol)block copolymers and method of manufacturing the same
Assignee: Wyeth Holdings LLC
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Filing: 1983-10-05
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Granted: —
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Expires: 2003-10-05
Abstract
Abstract Multiblock copolymers having the following general formula: where R represents alkylene and Ar is an aromatic group, are obtained by transesterification of poly(glycolic acid) and an hydroxyl-ended poly(alkylene glycol) such as poly(oxyethylene) in the presence of a catalyst with the degree of polymerization of the copolymer being increased by the subsequent addition of an aromatic orthocarbonate such as tetra-p-tolyl orthocarbonate. The copolymers find use in the manufacture of surgical articles, particularly absorbable monofilament sutures possessing the desired characteristics of flexibility, resulting in good handling properties, and biodegradability.
Inventors
- 👤 Donald James Casey
- 👤 Kenneth Robert Huffman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 22:02
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/12; A61L31/00; A61L31/04; A61L31/06
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
51 words
A multiblock copolymer useful for the manufacture of bioabsorbable surgical articles comprising the formula: wherein R represents an alkylene group and Ar is an aromatic group, the poly(glycolic acid) content is about 80 to 85 percent, the poly(oxyalkylene) content is about 20 to 15 percent, and n is 23 to 91.
Claim 2
Dependent Claim
51 words
A multiblock copolymer useful for the manufacture of bioabsorbable surgical articles comprising the formula: wherein R represents an alkylene group and Ar is an aromatic group, the poly(glycolic acid) content is about 80 to 85 percent, the poly(oxyalkylene) content is about 20 to 15 percent, and n is 23 to 91.
Claim 3
Dependent Claim
59 words
A hydrolyzable monofilament fiber formed from a multiblock copolymer comprising the formula: wherein R represents an alkylene group and Ar is an aromatic group, the poly(glycolic acid) content is about 80 to 85 percent, the poly(oxyalkylene) content is about 20 to 15 percent and n is 23 to 91, having a tensile modulus below 1 X 10 6 psi.
Claim 4
Dependent Claim
59 words
A hydrolyzable monofilament fiber formed from a multiblock copolymer comprising the formula: wherein R represents an alkylene group and Ar is an aromatic group, the poly(glycolic acid) content is about 80 to 85 percent, the poly(oxyalkylene) content is about 20 to 15 percent and n is 23 to 91, having a tensile modulus below 1 X 10 6 psi.
Claim 5
Dependent Claim
14 words
A multiblock copolymer as claimed in claim 1 or 2 where R is ethylene.
Claim 6
Dependent Claim
14 words
A multiblock copolymer as claimed in claim 3 wherein the aromatic group is tetra-p-tolyl.
Claim 7
Dependent Claim
15 words
A flexible monofilament suture or ligature manufactured from a copolymer as claimed in claim 4.
Claim 8
Independent Claim
40 words
A method of making a multiblock copolymer comprising transesterifying poly(glycolic) acid and a hydroxyl-ended poly(alkylene glycol), in the presence of a catalyst, and adding to the copolymer produced thereby, an aromatic orthocarbonate to extend the chain polymerization and reduce brittleness.
Claim 9
Independent Claim
40 words
A method of making a multiblock copolymer comprising transesterifying poly(glycolic) acid and a hydroxyl-ended poly(alkylene glycol), in the presence of a catalyst, and adding to the copolymer produced thereby, an aromatic orthocarbonate to extend the chain polymerization and reduce brittleness.
Claim 10
Dependent Claim
20 words
A method as claimed in claim 6 wherein the poly(alkylene glycol) is poly(oxyethylene) and the aromatic orthocarbonate is tetra-p-tolyl orthocarbonate.
Claim 11
Dependent Claim
52 words
A surgical article manufactured from copolymer made according to a method claimed in claim 6 or 7. 9 . A surgical article as claimed in claim 8 selected from the group consisting of a suture, ligature, needle and suture combination, surgical clip, surgical staple, surgical prosthesis, textile structure, coupling, tube, and support.
Claim 12
Dependent Claim
57 words
A composition for the controlled continuous administration of a predetermined dosage of a pharmaceutical drug to a living animal comprising a material selected from the group consisting of a self-supporting film, a hollow tube, a plurality of beads, and a gel, said material manufactured from a copolymer made according to a method of claim 6 or 7.
References Cited (Backward Citations)
No citation records indexed.
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