EP0107941A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Soft buccal
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1983-10-07
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Granted: —
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Expires: 2003-10-07
Abstract
Abstract A soft buccal containing (1) a medicament to be absorbed through the oral mucosa, (2) a water-soluble protein, (3) a polyhydric alcohol, and (4) a fatty acid ester or l and a carboxyvinyl polymer, has various advantages such as good feeling in use, good retainability within the mouth, slow release, improved absorbability of drug through the mucosa, improved bioavailability, etc., and therefore can be used an excellent pharmaceutical preparation for administration to the mucous membrane of the mouth.
Inventors
- 👤 Kazuo Kigasawa
- 👤 Hiroaki Shimizu
- 👤 Toshihiro Hayashi
- 👤 Kazuo Watabe
- 👤 Akira Tanizaki
- 👤 Osamu Koyama.
- 👤 Kikuo Wakisaka
- 👤 Yasuaki Ogawa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/0012; A61K9/0053; A61K9/006
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
33 words
A soft buccal which contains (1) a medicament to be absorbed through the oral mucosa; (2) a water-soluble protein; (3) a polyhydric alcohol; and (4) a fatty acid ester or/and a carboxyvinyl polymer.
Claim 2
Dependent Claim
33 words
A soft buccal which contains (1) a medicament to be absorbed through the oral mucosa; (2) a water-soluble protein; (3) a polyhydric alcohol; and (4) a fatty acid ester or/and a carboxyvinyl polymer.
Claim 3
Dependent Claim
35 words
A soft buccal as claimed in Claim l, wherein the water-soluble protein is at least one selected from gelatin; solubilized collagen; casein; glue; hydrolysates from gelatin, solubilized collagen, casein or glue; polyalanine; polylysine and polyglutamine.
Claim 4
Dependent Claim
14 words
A soft buccal as claimed in Claim 1, wherein the water-soluble protein is gelatin.
Claim 5
Dependent Claim
22 words
A soft buccal as claimed in Claim 1, wherein the polyhydric alcohol is at least one selected from glycol, triol and polyol.
Claim 6
Dependent Claim
65 words
A soft buccal as claimed in Claim 1, wherein the polyhydric alcohol is at least one selected from ethylene glycol; propylene glycol; butylene glycol; polyethylene glycol; glycerin; trimethylolpropane; polyvinyl alcohol; methylcellulose; ethylcellulose; propylcellulose; hydroxymethylcellulose; hydroxyethylcellulose; carboxymethylcellulose or an alkali metal salt thereof; glucose; galactose; fructose; mannose; mannitol; sorbitol; maltose; lactose; sucrose; carboxymethyl-starch; hydroxypropyl-starch; dextrin; dextran; chitin; alginic acid; glycogen; Furlan®; mannan; pectin; and gum arabic.
Claim 7
Dependent Claim
17 words
A soft buccal as claimed in Claim 1, wherein the polyhydric alcohol is glycerin or propylene glycol.
Claim 8
Dependent Claim
26 words
A soft buccal as claimed in Claim 1, wherein the fatty acid ester is a monoalcohol or polyalcohol ester of a saturated or unsaturated fatty acid.
Claim 9
Dependent Claim
19 words
A soft buccal as claimed in Claim 1, wherein the fatty acid ester is a sucrose fatty acid ester.
Claim 10
Dependent Claim
21 words
A soft buccal as claimed in Claim 1, wherein the carboxyvinyl polymer is polyacrylic acid, polymethacrylic acid or a salt thereof.
Claim 11
Dependent Claim
27 words
A base composition for a soft buccal which comprises (1) a water-soluble protein, (2) a polyhydric alcohol, and (3) a fatty acid ester or/and a carboxyvinyl polymer.
Claim 12
Dependent Claim
27 words
A base composition for a soft buccal which comprises (1) a water-soluble protein, (2) a polyhydric alcohol, and (3) a fatty acid ester or/and a carboxyvinyl polymer.
References Cited (Backward Citations)
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