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EP0107559B2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Process for homogenising dispersions of hydrated lipidic lamellar phases

Assignee: Parfums Christian Dior SA
•
Filing: 1983-10-06
•
Granted: 1997-12-17
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Expires: 2003-10-06
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Abstract

Abstract The invention concerns a method of homogenizing dispersions of hydrated lipidic lamellar phases and suspensions obtained thereby which can be applied particularly to the making of products intended for cosmetic, pharmaceutical and medical uses. The method consists in dispersing in a dispersion liquid a lipidic phase or a lipidic lamellar phase containing one or several amphiphilic lipids and then in homogenizing the said dispersion by feeding the same under a pressure comprised between 10,000 and 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element arranged in the section of the orifice adjustably, against the flow of the dispersion.

Inventors

  • 👤 Gérard Redziniak
  • 👤 Alain Meybeck

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 08:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; A61K8/00; A61K8/02; A61K8/14; A61K8/18; A61K8/96; A61K8/97; A61K8/9783; A61K8/9789; A61K8/9794; A61Q; A61Q19/00; B; B01; B01F; B01F25/00; B01F25/40; B01F25/44; B01F25/441; B01F25/4413; B01F25/442; B01F25/4422; B01F25/45; Y; Y10; Y10S; Y10S516/00; Y10S516/924; Y10S516/929; Y10S516/93; Y10S977/00; Y10S977/70; Y10S977/778; Y10S977/783; Y10S977/84; Y10S977/902; Y10S977/904; Y10S977/926; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 114 words
Method for the obtainment of a homogenized suspension of liposomes in an aqueous liquid containing a substance, consisting in dispersing lipidic components containing one or several amphiphilous lipids in the said aqueous liquid, then in homogenizing the dispersion of the liposomes obtained by feeding the latter at a pressure lying between 10,000 kPa and 70,000 kPa into a passageway of small width defined between the walls of an opening and the edges of a shutter element disposed in an adjustable manner in the section of the said opening, in opposition to the flow of the said dispersion, to thus achieve the increase of the rate of encapsulation of the said substance into the liposomes.
Claim 2
Dependent Claim 18 words
Method according to claim 1, characterized in that the feed pressure lies between 10,000 kPa and 40,000 kPa.
Claim 3
Dependent Claim 16 words
Method according to claim 1, characterized in that the aforesaid feed pressure is about 30,000 kPa.
Claim 4
Dependent Claim 36 words
Method according to one of claims 1 to 3, characterized in that one carries out several successive passages of the dispersion within the aforesaid passageway with possibly a cooling of the said dispersion between each passage.
Claim 5
Dependent Claim 35 words
Method according to one of the foregoing claims, characterized in that the dispersion to be homogenized is pre-fed under pressure into a device performing the feeding under pressure of the dispersion into the aforesaid passageway.
Claim 6
Dependent Claim 25 words
Method according to claim 7, characterized in that the said pre-feeding under pressure of the dispersion is carried out in an inert or non-oxidizing atmosphere.
Claim 7
Dependent Claim 29 words
Method according to one of the foregoing claims, characterized in that the aforesaid dispersion liquid is a solution of a product which is biologically active and/or has organoleptic properties.
Claim 8
Dependent Claim 28 words
Method according to one of claims 1 to 6, characterized in that the aforesaid liquid of the dispersion is an aqueous physiological solution of sodium chloride or d-glucose.

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