Patent US2903648A successfully refreshed from Google Patents.
EP0106341A2
Expired / Lapsed
EP
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Physiologically active substance P-23924, its production and use
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1983-10-15
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Granted: —
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Expires: 2003-10-15
Abstract
Abstract The compound of the formula: wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, R 3 is hydroxy or methoxy, and R 4 is hydrogen or a group is novel, and the compound is of use as inhibitors of animal tissue fibrosis or biochemical reagents.
Inventors
- 👤 Hisayoshi Okazaki
- 👤 Kazuhiko Ohta
- 👤 Takenori Ishimaru
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 14:39
CPC Classifications
C; C07; C07C; C07C46/00; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C07C50/00; C07C50/26; C07C50/32; C12P; C12P13/00; C12P13/04; C12P7/00; C12P7/66; C12R; C12R2001/00; C12R2001/01; C12R2001/465
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
34 words
A compound represented by the formula: wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, R 3 is hydroxy or methoxy and R 4 is hydrogen or a group
Claim 2
Dependent Claim
34 words
A compound represented by the formula: wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, R 3 is hydroxy or methoxy and R 4 is hydrogen or a group
Claim 3
Dependent Claim
13 words
A compound as claimed in Claim 1, wherein R 4 is a group
Claim 4
Dependent Claim
12 words
A compound as claimed in Claim 1, wherein R 4 is hydrogen.
Claim 5
Dependent Claim
36 words
A compound as claimed in Claim 1, wherein the compound is Physiologically Active Substance P-23924C (the compound wherein R 1 is hydrogen, R 2 is methoxy, R 3 is methoxy and R 4 is a group
Claim 6
Dependent Claim
120 words
A compound as claimed in Claim 1, wherein the compound is Physiologically Active Substance P -2 3 924 B (the compound wherein R 1 is methyl, R 2 is methoxy, R 3 is methoxy and R 4 is a group Physiologically Active Substance P-23924 D (The compound wherein R 1 is methyl R 2 is methoxy, R 3 is hydroxy and R 4 is a group Physiologically Active Substance P -23924E (the compound wherein R 1 is hydroxymethyl, R 2 is hydrogen, R 3 is methoxy and R 4 is a group , or Physiologically Active Substance P-23924 F (the compound wherein R 1 is hydroxymethyl, R 2 is methoxy, R 3 is methoxy and R 4 is a group
Claim 7
Dependent Claim
112 words
A compound as claimed is Claim 1, wherein the compound is Physiologically Active Substance P-23924AR (the compound whereir. R 1 is methyl, R 2 is hydrogen, R 3 is methoxy and R 4 is hydrogen), Physiologically Active Substance P-23924 BR (the compound wherein R 1 is methyl, R 2 is methoxy, R 3 is methoxy and R 4 is hydrogen.), Physiologically Active Substance P-23924 CR (the compound wherein R 1 is hydrogen, R 2 is methoxy, R 3 is methoxy and R 4 is hydrogen.), or ?hysiologically Active Substance P -23924 DR (the compound wherein R 1 is methyl, R 2 is methoxy, R 3 is hydroxy and R 4 is hydrogen.).
Claim 8
Independent Claim
72 words
A method of prciucing Physiologically Active Substance P-23924 A, 3, C, D, E and/or F, characterized by cultivating a microorganism belonging to the genus Streptomyces and capable of elaborating Physiologically Active Substance P-23924 A, B, C,D, E and/or F in a medium to cause said microorganism to elaborate and accumulate Physiologically Active Substance P-23924 A, B, C, D , E and/or F and recovering the same substance from the resulting culture brcth.
Claim 9
Independent Claim
72 words
A method of prciucing Physiologically Active Substance P-23924 A, 3, C, D, E and/or F, characterized by cultivating a microorganism belonging to the genus Streptomyces and capable of elaborating Physiologically Active Substance P-23924 A, B, C,D, E and/or F in a medium to cause said microorganism to elaborate and accumulate Physiologically Active Substance P-23924 A, B, C, D , E and/or F and recovering the same substance from the resulting culture brcth.
Claim 10
Dependent Claim
17 words
A method as claimed in Claim 7, wherein the microorganism is Streptomyces sp. No. 23924 (FERM BP-338).
Claim 11
Independent Claim
57 words
A method of prcducing a compound represented by the formula: wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, and R 3 is hydroxy or methoxy, which comprises subjecting to reduction a compound of the formula: wherein R 1 , R 2 and R 3 has the same meanings as defined above.
Claim 12
Independent Claim
57 words
A method of prcducing a compound represented by the formula: wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, and R 3 is hydroxy or methoxy, which comprises subjecting to reduction a compound of the formula: wherein R 1 , R 2 and R 3 has the same meanings as defined above.
Claim 13
Dependent Claim
8 words
An antifibrotic preparation containing Physiologically Active Substance P-23924.
Claim 14
Dependent Claim
8 words
An antifibrotic preparation containing Physiologically Active Substance P-23924.
References Cited (Backward Citations)
No citation records indexed.
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