Patent US2515968A successfully refreshed from Google Patents.
EP0103947A2
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Method for inhibiting mineralization of natural tissue during implantation
Assignee: Janssen Pharmaceuticals Inc
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Filing: 1983-07-04
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Granted: —
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Expires: 2003-07-04
Abstract
Abstract Natural tissues fixed with a tanning solution such as glutaraldehyde and intended for implantation in humans, e.g., porcine heart valve prosthetic devices, are treated with a solution of a water soluble phosphate ester such as sodium dodecyl hydrogen phosphate to inhibit mineralization, particularly calcification, of the tissue after implantation.
Inventors
- 👤 Elisabeth Marie Pollock
- 👤 David John Lentz
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 23:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
62 words
. A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble phosphate ester having the formula wherein at least one of R 1 , R 2 and R 3 is an alkyl group having from 7 to 15 carbon atoms.
Claim 2
Dependent Claim
62 words
. A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble phosphate ester having the formula wherein at least one of R 1 , R 2 and R 3 is an alkyl group having from 7 to 15 carbon atoms.
Claim 3
Dependent Claim
19 words
The method of Claim 1 wherein the pH of the aqueous solution ranges from about 2 to about 10.
Claim 4
Dependent Claim
15 words
or Claim 2 3. The method of Claim 1/wherein said-phosphate ester is a monoalkyl ester.
Claim 5
Dependent Claim
19 words
2 or 3, or each 4. The method of Claim 1/wherein the/alkyl group is a straight chain aliphatic group.
Claim 6
Dependent Claim
18 words
2 or 3, or each 5. The method of Claim 1,/wherein the/alkyl group is a branched aliphatic group.
Claim 7
Dependent Claim
41 words
or Claim 2 6. The method of Claim 1/wherein R 1 is an alkyl group having from 7 to 15 carbons, R 2 is hydrogen, and R 3 is selected from the group consisting of sodium, potassium, ammonium and organic amine.
Claim 8
Dependent Claim
23 words
Claim 3 or 7. The method of/Claim 6 wherein said alkyl group is selected from the group consisting of decyl, dodecyl and myristyl.
Claim 9
Dependent Claim
15 words
Claim 3 or 8. The method of/Claim 6 wherein,said alkyl group is a dodecyl group.
Claim 10
Dependent Claim
32 words
any one of to 8 9. The method of/Clairrs 1/wherein said natural tissue is contacted with said solution for a time sufficient to effectively inhibit future calcification of said tissue after implant.
Claim 11
Dependent Claim
32 words
any one of to 8 9. The method of/Clairrs 1/wherein said natural tissue is contacted with said solution for a time sufficient to effectively inhibit future calcification of said tissue after implant.
Claim 12
Dependent Claim
28 words
any one of to 9 10. The method of/Claimsl/wherein said natural tissue is contacted with said solution for a period of at least 24 hours at ambient temperature.
Claim 13
Dependent Claim
26 words
any one of to 10 11. The method of/Claimsl/wherein the concentration of said phosphate ester in said solution is from about 0.1 to 5% by weight.
Claim 14
Dependent Claim
57 words
any one of to 11 12. The method of/Claims 1 /wherein said solution comprises, in addition to said phosphate ester, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 15
Dependent Claim
56 words
anyone of to 11 13 . The method of/Claims 1/ wherein said solution comprises, in addition to said phosphate ester, about 0.8% by weight of sodium chloride, about 0.04% by weight of potassium chloride, about 0.02% by weight each of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 16
Dependent Claim
18 words
anyone of to 13 14. The method of/Claims 1/ wherein the pH of said solution is about 3.
Claim 17
Independent Claim
46 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl hydrogen phosphate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 18
Independent Claim
46 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl hydrogen phosphate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 19
Dependent Claim
22 words
16 . The method of Claim 15 wherein said solution comprises from about 0.1 to 5% by weight sodium dodecyl hydrogen phosphate.
Claim 20
Dependent Claim
26 words
15 or Claim 17 . The method of Claim/16 wherein said tissue is contacted with said solution for a time of at least about 7 days.
Claim 21
Dependent Claim
21 words
15, or 17 18 . The method of Claim/16,/wherein the pH of said solution ranges from about 2 to about 10.
Claim 22
Dependent Claim
21 words
any one of to 18 19. The method of /Claims 15/wherein the concentration of sodium dodecyl hydrogen phosphate is about 1%.
Claim 23
Dependent Claim
31 words
anyone of to 19 20. The method of/Clairas 15/wherein the tissue is contacted with said solution of sodium dodecyl hydrogen phosphate for a period of about 7 days at ambient temperature.
Claim 24
Dependent Claim
31 words
anyone of to 19 20. The method of/Clairas 15/wherein the tissue is contacted with said solution of sodium dodecyl hydrogen phosphate for a period of about 7 days at ambient temperature.
Claim 25
Dependent Claim
59 words
any one of to 20 21. The method of/Claim s 15/ wherein said solution includes, in addition to sodium dodecyl hydrogen phosphate, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 26
Dependent Claim
52 words
anyone of to 20 22 . The method of/Claims 15/wherein said solution includes, in addition to sodium dodecyl hydrogen phosphate, about 0.8% by weight sodium chloride, about 0.04% potassium chloride, about 0.02% by weight each of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 27
Dependent Claim
19 words
any one of to 22 23 . The method of/Claims 15/wherein the pH of said solution is about 3.
Claim 28
Dependent Claim
20 words
anyone of to 23 24 . The method of/Claims 1 /wherein the fixed tissue is a glutaraldehyde-fixed porcine heart valve.
Claim 29
Dependent Claim
19 words
any one of to 24 25 . The method of /Claims 1/ wherein said living body is a human.
References Cited (Backward Citations)
No citation records indexed.
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