Patent FR2622458A1 successfully refreshed from Google Patents.
EP0103361A1
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Quinone compounds, their production and use
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1983-06-28
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Granted: —
•
Expires: 2003-06-28
Abstract
Abstract New quinone compounds of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or their hydroquinone-form compounds, or pharmaceutically acceptable salts thereof, have useful physiological activities such as antiasthmatic and antiallergic activities.
Inventors
- 👤 Shinji Terao
- 👤 Yoshitaka Maki
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 08:15
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07C; C07C46/00; C07C47/00; C07C47/20; C07C47/228; C07C47/232; C07C50/00; C07C50/38; C07C66/00
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
51 words
A compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
51 words
A compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
15 words
A compound as claimed in Claim 1, wherein the compound is in the quinone form.
Claim 4
Dependent Claim
11 words
A compound as claimed in Claim 1, wherein Y is carboxyl.
Claim 5
Dependent Claim
11 words
A compound as claimed in Claim 1, wherein Y is carbamoyloxymethyl.
Claim 6
Dependent Claim
12 words
A compound as claimed in Claim 1, wherein the compound is 2-(11-carboxyundeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone.
Claim 7
Dependent Claim
13 words
A compound as claimed in Claim 1, wherein the compound is 2-(11-carboxyundeca-5,10-diynyl)-5,6-dimethoxy-3-methyl 1,4-benzoquinone.
Claim 8
Dependent Claim
12 words
A compound as claimed in Claim 1, wherein the compound is 2-(12-carbamoyloxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone.
Claim 9
Dependent Claim
12 words
A compound as claimed in Claim 1, wherein the compound is 2-(12-carbamoyloxydodeca-5,10-diynyl)-5,6-dimethoxy-3-methyl-l,4-benzoquinone.
Claim 10
Dependent Claim
35 words
A pharmaceutical composition which comprises, as an active ingredient, an effective amount of a compound as claimed in any one of claims 1 to 8 in association with a pharmaceutically acceptable carrier or excipient therefor.
Claim 11
Dependent Claim
29 words
A compound as claimed in any one of Claim 1 to 8 or a pharmaceutical composition as claimed in Claim 9 for use in therapeutical treatment of a mammal.
Claim 12
Dependent Claim
82 words
A process for producing a compound of a formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms carbamoyl, a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone form, which comprises subjecting a compound of the formula: wherein R and Y are as defined above, and R is an alkyl having 1 to 3 carbon atoms, benzyl, methoxymethly or tetrahydropyranyl, to deprotection reaction.
Claim 13
Dependent Claim
82 words
A process for producing a compound of a formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms carbamoyl, a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone form, which comprises subjecting a compound of the formula: wherein R and Y are as defined above, and R is an alkyl having 1 to 3 carbon atoms, benzyl, methoxymethly or tetrahydropyranyl, to deprotection reaction.
Claim 14
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 1 is formyl or carboxyl, which comprises oxidizing a compound of the formula: wherein R is of the meaning given above.
Claim 15
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 1 is formyl or carboxyl, which comprises oxidizing a compound of the formula: wherein R is of the meaning given above.
Claim 16
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 2 is carbamoyloxymethyl, which comprises subjecting a compound of the formula: wherein R is of the meaning given above, to carbamoylation.
Claim 17
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 2 is carbamoyloxymethyl, which comprises subjecting a compound of the formula: wherein R is of the meaning given above, to carbamoylation.
Claim 18
Dependent Claim
68 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, which comprises reducing a compound of the formula: wherein R and Y are of the meaning given above. CLAIMS (for the contracting State AT):
Claim 19
Dependent Claim
83 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone form, which comprises subjecting a compound of the formula: wherein R and Y are as defined above, and R is an alkyl having 1 to 3 carbon atoms, benzyl, methoxymethyl or tetrahydropyranyl, to a deprotection reaction.
Claim 20
Dependent Claim
83 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, or its hydroquinone form, which comprises subjecting a compound of the formula: wherein R and Y are as defined above, and R is an alkyl having 1 to 3 carbon atoms, benzyl, methoxymethyl or tetrahydropyranyl, to a deprotection reaction.
Claim 21
Dependent Claim
26 words
A process as claimed in claim 1, wherein R is C 1 -C 3 alkyl or benzyl, and the compound (II) is subjected to oxidative dealkylation.
Claim 22
Dependent Claim
21 words
A process as claimed in claim 1, wherein R is methoxynethyl or tetrahydropyranyl, and the compound (II) is subjected to solvolysis.
Claim 23
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 1 is formyl or carboxyl, which comprises oxidizing a compound of the formula: wherein R is of the meaning given above.
Claim 24
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 1 is formyl or carboxyl, which comprises oxidizing a compound of the formula: wherein R is of the meaning given above.
Claim 25
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 2 is carbamoyloxymethyl, which comprises subjecting a compound of the formula: wherein R is of the meaning given above, to carbamoylation.
Claim 26
Dependent Claim
38 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y 2 is carbamoyloxymethyl, which comprises subjecting a compound of the formula: wherein R is of the meaning given above, to carbamoylation.
Claim 27
Dependent Claim
40 words
A process for producing a compound of the formula: wherein Y is alkoxycarbonyl group having 2 to 5 carbon atoms and R is methyl or methoxy, which comprises esterifying a compound of the formula: wherein R is as defined above.
Claim 28
Dependent Claim
40 words
A process for producing a compound of the formula: wherein Y is alkoxycarbonyl group having 2 to 5 carbon atoms and R is methyl or methoxy, which comprises esterifying a compound of the formula: wherein R is as defined above.
Claim 29
Dependent Claim
52 words
A process for producing a compound of the formula: wherein Y 4 is carbamoyl or a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms and R is methyl or methoxy, which comprises subjecting a compound of the formula: wherein R is as defined above, to an amidation reaction.
Claim 30
Dependent Claim
52 words
A process for producing a compound of the formula: wherein Y 4 is carbamoyl or a mono- or di-alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms and R is methyl or methoxy, which comprises subjecting a compound of the formula: wherein R is as defined above, to an amidation reaction.
Claim 31
Dependent Claim
62 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di-alkylcarbamoyl whose moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, which comprises • reducing a compound of the formula: wherein P and Y are of the meaning given above.
Claim 32
Dependent Claim
62 words
A process for producing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di-alkylcarbamoyl whose moiety has 1 to 4 carbon atoms, or carbamoyloxymethyl, which comprises • reducing a compound of the formula: wherein P and Y are of the meaning given above.
Claim 33
Dependent Claim
68 words
A process for preparing a pharmaceutical composition, which comprises mixing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof, with a pharmaceutically acceptable carrier or excipient.
Claim 34
Dependent Claim
68 words
A process for preparing a pharmaceutical composition, which comprises mixing a compound of the formula: wherein R is methyl or methoxy and Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or its hydroquinone-form compound, or a pharmaceutically acceptable salt thereof, with a pharmaceutically acceptable carrier or excipient.
References Cited (Backward Citations)
GB2055097A
Cited
EP0038160A1
Cited
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