EP0089152A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Hydrophilic bipolymeric copolyelectrolytes, and biodegradable wound dressings comprising same
Assignee: University of Illinois at Urbana-Champaign
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Filing: 1983-03-03
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Granted: —
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Expires: 2003-03-03
Abstract
Abstract Hydrophilic biopolymeric copolyelectrolytes are prepared from (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, such as ammonium keratinate, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from a glucosaminoglycan andior collagen, such as chitosan acetate andior collagen acetate. Hydrogel membranes formed from the copolyelectrolytes are useful as biodegradable dressings for burn wounds and other denuded tissue wound sites.
Inventors
- 👤 Abe Widra
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 15:50
CPC Classifications
C; C08; C08L; C08L5/00; C08L5/08; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61P; A61P17/00; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003; C08H; C08H1/00; C08H1/06; C08L89/00; C08L89/04; C08L89/06; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
37 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from a glucosaminoglycan and collagen.
Claim 2
Dependent Claim
37 words
A hydrophilic biopolymeric copolyelectrolyte of (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin, and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from a glucosaminoglycan and collagen.
Claim 3
Dependent Claim
14 words
The copolyelectrolyte of Claim 1, wherein said anionic protein polyelectrolyte component is ammonium keratinate.
Claim 4
Dependent Claim
15 words
The copolyelectrolyte of Claim 2, wherein the keratin moiety of said ammonium keratinate is alpha-keratose.
Claim 5
Dependent Claim
11 words
The copolyelectrolyte of any preceding claim, wherein said glucosaminoglycan is chitosan.
Claim 6
Dependent Claim
16 words
The copolyelectrolyte of any preceding claim, wherein said cationic biopolymer polyelectrolyte component is a biopolymer carboxylate.
Claim 7
Dependent Claim
13 words
The copolyelectrolyte of Claim 5, wherein said biopolymer carboxylate is a biopolymer acetate.
Claim 8
Dependent Claim
32 words
The copolyelectrolyte of Claim 1, wherein the weight ratio of said anionic protein polyelectrolyte component to said cationic biopolymer polyelectrolyte component is within the range of from about 1:1 to about 10:1.
Claim 9
Dependent Claim
32 words
The copolyelectrolyte of Claim 7, wherein the weight ratio of said anionic protein polyelectrolyte component to said cationic biopolymer polyelectrolyte component is within the range of from about 2:1 to about 5:1.
Claim 10
Dependent Claim
36 words
The copolyelectrolyte of Claim 8, wherein the biopolymer moiety of said cationic biopolymer polyelectrolyte component is a mixture of chitosan and collagen in a chitosan to collagen weight ratio of from about 0.5:1 to about 2:1.
Claim 11
Dependent Claim
29 words
The copolyelectrolyte of Claim 9, wherein said anionic protein polyelectrolyte component is ammonium keratinate, and said cationic biopolymer polyelectrolyte component is a mixture of chitosan acetate and collagen acetate.
Claim 12
Dependent Claim
27 words
The copolyelectrolyte of Claim 8, wherein said anionic protein polyelectrolyte component is ammonium keratinate, and said cationic biopolymer polyelectrolyte component is either chitosan acetate or collagen acetate.
Claim 13
Dependent Claim
18 words
The copolyelectrolyte of Claim 10 or Claim 11, wherein the keratin moiety of said ammonium keratinate is alpha-keratose.
Claim 14
Dependent Claim
20 words
A composition comprising the copolyelectrolyte of any preceding claim, and a flexibility-and/or adhesion-enhancing amount of a non-toxic plasticizer or softener.
Claim 15
Dependent Claim
12 words
The composition of Claim 13, wherein said plasticizer or softener is glycerol.
Claim 16
Dependent Claim
14 words
A hydrogel comprising the copolyelectrolyte of any one of Claims 1-12 in hydrated form.
Claim 17
Dependent Claim
24 words
A membrane comprising at least one layer of the hydrogel of Claim 15, said membrane having a thickness of at least about 1 mil.
Claim 18
Dependent Claim
26 words
The membrane of Claim 16, wherein both cationic chitosan and cationic collagen are present either in the same hydrogel layer or in two separate hydrogel layers.
Claim 19
Dependent Claim
21 words
A biodegradable dressing for burn wounds and other denuded tissue wound sites, comprising the membrane of Claim 16 or Claim 17.
Claim 20
Dependent Claim
19 words
The dressing of Claim 18, wherein said membrane includes a flexibility-and/or adliesion-enliancing amount of a non-toxic plasticizer or softener.
References Cited (Backward Citations)
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