EP0076355A2
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EP
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Improved peritoneal dialysis solution
Assignee: Abbott Laboratories
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Filing: 1982-02-12
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Granted: —
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Expires: 2002-02-12
Abstract
Abstract An improved peritoneal dialysis solution comprises the conventional electrolyte combination of sodium, calcium, magnesium, chloride, lactate, and sodium hydroxide, the improvement comprising the use of a glucose polymer as the osmotic agent. In a preferred embodiment, the glucose polymer is found in a concentration of from 30 to 125 grams per liter. The large size of the glucose polymer molecules delays their passage through the peritoneum. In addition, the large glucose polymer molecules are slow to be metabolized in the blood. As a result, caloric intake is reduced and the length of time selective osmotic pressure may be applied is increased. Better B.U.N. (Blood Urea and Nitrogen) and creatinine clearances are thereby obtained, and the number of dialyses required can be reduced. Also disclosed is a method of use thereof.
Inventors
- 👤 Anne Barlow Ramsay
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:48
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/28; A61M1/287; A61K; A61K31/00; A61K31/70; A61K31/715
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
57 words
An autoclavable peritoneal dialysis solution comprising : 10-125 g/liter glucose polymer; electrolytes comprising approximately: sodium 132-145 m Eq., calcium 3.5-4 m Eq; magnesium 1.5 m Eq., chloride 99-101 m Eq.; lactate 35 m Eq., and sodium - hydroxide of from 340 to 485 m mOsm/L for purposes of adjusting the pH of said solution to approximately 5.5.
Claim 2
Dependent Claim
57 words
An autoclavable peritoneal dialysis solution comprising : 10-125 g/liter glucose polymer; electrolytes comprising approximately: sodium 132-145 m Eq., calcium 3.5-4 m Eq; magnesium 1.5 m Eq., chloride 99-101 m Eq.; lactate 35 m Eq., and sodium - hydroxide of from 340 to 485 m mOsm/L for purposes of adjusting the pH of said solution to approximately 5.5.
Claim 3
Dependent Claim
50 words
The solution as disclosed in Claim 1 wherein, in each 100 milliliter quantity of said solution, said electrolytes consist essentially of sodium lactate anhydrous 392 mg/100 ml; sodium chloride 550 mg/100 ml; calcium choride dihydrate 25.7 mg/100 ml; magnesium chloride, hexahydrate 15.2 mg/100 ml; and sodium metabisulfite 30 mg/100 ml.
Claim 4
Dependent Claim
38 words
The solution as disclosed in Claim 1 wherein said glucose polymer comprises between 1 and 13% glucose polymer, said solution being substantially equivalent to between 1.5 and 4.25% dextrose solution in osmolality, i.e., between approximately 344 and 483.
Claim 5
Dependent Claim
63 words
The peritoneal dialysis solution as disclosed in Claim 1 wherein said glucose polymer comprises a glucose polymer mixture having an average degree of polymerization of at least 4 and at least 99% of its molecules less than 26 glucose units, at least 85% of its molecules less than 11 glucose units, and at least 20% of its molecules less than 4 glucose units.
Claim 6
Dependent Claim
41 words
A peritoneal dialysis solution containing the following ingredients in the approximate concentration of: 132 m Eq/L sodium 99 m Eq/L chloride 35 m Eq/L lactate 1.5 m Eq/L magnesium 3.5 m Eq/L calcium; and from 10 to 125 g/L glucose polymers.
Claim 7
Dependent Claim
41 words
A peritoneal dialysis solution containing the following ingredients in the approximate concentration of: 132 m Eq/L sodium 99 m Eq/L chloride 35 m Eq/L lactate 1.5 m Eq/L magnesium 3.5 m Eq/L calcium; and from 10 to 125 g/L glucose polymers.
Claim 8
Dependent Claim
18 words
The solution defined in Claim 1 or 2, or 5 wherein the solution is hypotonic to human blood.
Claim 9
Dependent Claim
25 words
The solution defined in Claim 1 or 2 or 5 wherein said glucose polymer mixture has an average degree of polymerization between 4 and 10.
Claim 10
Dependent Claim
134 words
The solution defined in Claim 1, 2 or 5 wherein said solution has an average degree of polymerization between 4 and 6, less than 1% of its molecules greater than 25 glucose units, 4 to 10% of its molecules between 11 and 25 glucose units, 1 to 3% of its molecules 10 glucose units, 3 to 5% of its molecules 9 glucose units, 5 to 8% of its molecules 8 glucose units, 14 to 17% of its molecules 7 glucose units, 16 to 18% of its molecules 6 glucose units,-8 to 9% of its molecules 5 glucose units, 10 to 13%.of its molecules 4 glucose units, 13 to 17% of its molecules 3 glucose units, 8 to 13% of its molecules 2 glucose units, and 1 to 3% of its molecules 1 glucose unit.
Claim 11
Dependent Claim
56 words
An autoclavable peritoneal dialysis solution comprising : 10-125 g/liter glucose polymer; electrolytes comprising approximately: sodium 132-145 m Eq., calcium 3.5-4 m Eq; magnesium 1.5 m Eq., chloride 99-101 m Eq.; acetate 33 m Eq., and sodium hydroxide of from 340 to 485 m mOsm/L for purposes of adjusting the pH of said solution to approximately 5.5.
Claim 12
Dependent Claim
56 words
An autoclavable peritoneal dialysis solution comprising : 10-125 g/liter glucose polymer; electrolytes comprising approximately: sodium 132-145 m Eq., calcium 3.5-4 m Eq; magnesium 1.5 m Eq., chloride 99-101 m Eq.; acetate 33 m Eq., and sodium hydroxide of from 340 to 485 m mOsm/L for purposes of adjusting the pH of said solution to approximately 5.5.
Claim 13
Dependent Claim
50 words
The solution as disclosed in Claim 1 wherein, in each 100 milliliter quantity of said solution, said electrolytes consist essentially of sodium acetate 271 mg/100 ml; sodium chloride 562 mg/L00 ml; calcium choride dihydrate 25.7 mg/LOO ml; magnesium chloride, hexahydrate 15.2 mg/100 ml; and sodium - metabisulfite 27.4 mg/100 ml.
Claim 14
Dependent Claim
38 words
The solution as disclosed in Claim 1 wherein said glucose polymer comprises between 1 and 13% glucose polymer, said solution being substantially equivalent to between 1.5 and 4.25% dextrose solution in osmolality, i.e., between approximately 344 and 483.
Claim 15
Dependent Claim
63 words
The peritoneal dialysis solution as disclosed in Claim 1 wherein said glucose polymer comprises a glucose polymer mixture having an average degree of polymerization of at least 4 and at least 99% of its molecules less than 26 glucose units, at least 85% of its molecules less than 11 glucose units, and at least 20% of its molecules less than 4 glucose units.
Claim 16
Dependent Claim
42 words
A peritoneal dialysis solution containing the following ingredients in the approximate concentration of: . 132 m Eq/l sodium 99 m Eq/l chloride 35 m Eq/l lactate 1.5 m Eq/1 magnesium 3.5 m Eq/l calcium; and from 10 to 125 g/L glucose polymers.
Claim 17
Dependent Claim
42 words
A peritoneal dialysis solution containing the following ingredients in the approximate concentration of: . 132 m Eq/l sodium 99 m Eq/l chloride 35 m Eq/l lactate 1.5 m Eq/1 magnesium 3.5 m Eq/l calcium; and from 10 to 125 g/L glucose polymers.
Claim 18
Dependent Claim
18 words
14 . The solution defined in Claims 1 - 13 wherein the solution is hypotonic to human blood.
Claim 19
Dependent Claim
23 words
The solution defined in Claims 1 - 14 wherein said glucose polymer mixture has an average degree of polymerization between 4 and 10.
Claim 20
Dependent Claim
136 words
1 6. The solution defined in Claims 1 - 15 wherein said solution has an average degree of polymerization between 4 and 6, less than 1% of its molecules greater than 25 glucose units, 4 to 10% of its molecules between 11 and 25 glucose units, 1 to 3% of its molecules 10 glucose units, 3 to 5% of its molecules 9 glucose units, 5 to 8% of its molecules 8 glucose units, 14 to 17% of its molecules 7 glucose units, 16 to 18% of its molecules 6 glucose units, 8 to 9% of its molecules 5 glucose units, 10 to 13%.of its molecules 4 glucose units, 13 to 17% of its molecules 3 glucose units, 8 to 13% of its molecules 2 glucose units, and 1 to 3% of its molecules 1 glucose unit.
Claim 21
Dependent Claim
32 words
The solution as disclosed in Claim 1 or 2 or 3 or 5 or 6 or 16 or 20 or 21 wherein said glucose polymer mixture has the following distribution of polymers:
References Cited (Backward Citations)
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