Dry preparation containing fibrinogene, its production and use

Abstract

Abstract The dry preparation has a foamed or nonwoven structure obtained by freeze-drying and consists, in addition to thrombin in at least catalytically active amounts, essentially of approximately 10 to 95% by weight of fibrin and approximately 5 to 90% by weight of fibrinogen. For its production, fibrin is produced in situ in a fibrinogen- and thrombin-containing aqueous solution, and the resulting reaction mixture is deep-frozen and lyophilised. Further possible constituents of the dry preparation are active substances such as antibiotics, natural bone material and/or synthetic, bone- forming substitute material, glycoproteins, coagulation-promoting substances and the like, and/or fibrinolysis inhibitors. The dry preparation is intended primarily as a material for wound treatment, a filling material for bone cavities and/or as a support material for additional active substances.

Inventors

• 👤 Michael Stroetmann

Bibliographic Details