Method of producing a tricalcium phosphate bone ceramic for application as a bone implant, especially to fill cavities or for setting bone fractures in place after fracture, and tricalcium phosphate ceramic shaped articles produced according to this method

Claim 1

Process for the production of a fired tricalcium phosphate bone implant which is impregnated with an active substance and has a depot effect, which implant is formed of a fired moulded body to which active substances are added and which comprises a film-forming polymer for the delayed release of active substances, more especially for filling cavities or for fixing bone fragments after fractures, characterised in that the tricalcium phosphate, prior to the firing operation, has added thereto, inorganic and/or organic substances which form micropores or macropores, such as hydrogen peroxide, sugar, ammonium bicarbonate and/or ammonium car- baminate, calcium hydrogen phosphate, so as to form defined pore sizes, and the mass as thus obtained is moulded and fired, that then the ceramic shaped ceramic element as thus obtained is impregnated with an active substance, such as a disinfecting agent, an antiseptic agent, a chemotherapeutic agent or a broad-band microbicide, such as polyvinyl pyrrolidone iodine, and that the prepared ceramic shaped element is thereafter coated with a polymer, more especially polydextrane, in a prescribed layer thickness.