EP0054799A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
A dried, sterilized, gamma-globulin-fixed column and a process for preparing the same
Assignee: Asahi Kasei Corp
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Filing: 1981-12-04
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Granted: —
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Expires: 2001-12-04
Abstract
Abstract A dried, sterilized column containing a carrier-fixed y-globulin capable of specifically combining with various harmful substances found in blood of patients suffering from certain diseases and acting as an antibody. The y-globulin fixed column according to the present invention has a prolonged storage stability, and an excellent activity and safety even after the storage for a prolonged period of time as compared with unsterilized columns. Therefore, the y-globulin fixed column according to the present invention may be advantageously used for medical instrument applications.
Inventors
- 👤 Hiroshi Hayashi
- 👤 Takao Kiyota
- 👤 Mitsuru Shibuakawa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:57
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; A61K; A61K39/00; A61K39/395; A61K39/44; A61L; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
27 words
A δ-globulin fixed column characterized in that a carrier .having δ-globulin borne thereby and fixed thereto is packed in a dried and sterilized state into a column.
Claim 2
Dependent Claim
27 words
A δ-globulin fixed column characterized in that a carrier .having δ-globulin borne thereby and fixed thereto is packed in a dried and sterilized state into a column.
Claim 3
Dependent Claim
35 words
A column according to claim 1, wherein said borne δ-globulin is at least one member selected from the group consisting of anti-human-α-fetoprotein-δ-globulin, anti-human-ferritin-T-globulin, anti-B type hepatitis virus antigen δ-globulin, anti-anti-nuclear antibody-δ-globulin and anti-human-acetylcholine receptor antibody-δ-globulin.
Claim 4
Dependent Claim
14 words
A column according to claim l,wherein said carrier is of an agarose type resin.
Claim 5
Dependent Claim
16 words
A column according to claim 1, wherein said carrier is of a polyvinyl alcohol type resin.
Claim 6
Dependent Claim
40 words
A process for preparing a dried, sterilized δ-globulin - fixed column characterized in that a carrier having globulin borne thereby and fixed thereto is subjected to drying treatment and then to sterilization with ethylene oxide gas or propylene oxide gas.
Claim 7
Dependent Claim
40 words
A process for preparing a dried, sterilized δ-globulin - fixed column characterized in that a carrier having globulin borne thereby and fixed thereto is subjected to drying treatment and then to sterilization with ethylene oxide gas or propylene oxide gas.
Claim 8
Dependent Claim
12 words
A process according to claim 5, wherein said drying treatment is lyophilization.
Claim 9
Dependent Claim
36 words
A process according to claim 6, wherein prior to the lyophilization said δ-globulin fixed column is equilibrated with a 1-20% aqueous solution of a sugar selected from the group consisting of mannose, lactose, sucrose and glucose.
Claim 10
Dependent Claim
20 words
A process according to claim 7, wherein said aqueous solution of a sugar is a 5-15% aqueous solution of glucose.
Claim 11
Dependent Claim
39 words
A process according to any of claims 5 to 8, wherein said borne δ-globulin is at least one member selected from the group consisting of anti-human-α-fetoprotein-δ-globuiin, anti-human-ferritin-δ-globulin, anti-B type hepatitis virus antigen δ-globulin, anti-anti-nuclear antibody-δ-globuiin and anti-human-acetylcholine receptor antibody-a-globulin.
Claim 12
Dependent Claim
15 words
A process according to claim 5, wherein said carrier is of an agarose type resin.
Claim 13
Dependent Claim
16 words
A process according to claim 5, wherein said carrier is of a polyvinyl alcohol type resin.
Claim 14
Dependent Claim
15 words
A process according to claim 5, wherein said sterilization is effected using ethylene oxide gas.
References Cited (Backward Citations)
No citation records indexed.
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