EP0038546A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
99m Tc labeled diagnostic compositions and method for making the same
Assignee: General Hospital Corp
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Filing: 1981-04-16
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Granted: —
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Expires: 2001-04-16
Abstract
Abstract Protein molecules are covalently bonded to a chelating agent which in turn binds a radioactive molecule. Prior to binding, the radioactive molecule is reduced with dithionite ion and then mixed with protein at a pH of 7.0 to about 8.0.
Inventors
- 👤 Edgar Haber
- 👤 Ban An Khaw
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:25
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; A61K51/10; A61K51/1093; A61K2123/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
22 words
A composition comprising a protein covalently bound to a bifunctional chelating agent and a radioactive molecule being bound to said chelating agent.
Claim 2
Dependent Claim
22 words
A composition comprising a protein covalently bound to a bifunctional chelating agent and a radioactive molecule being bound to said chelating agent.
Claim 3
Dependent Claim
11 words
The compostition of claim 1 wherein said radioactive molecule is technetium-99m.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein said chelating agent is diethylene triamine pentaacetic acid.
Claim 5
Dependent Claim
14 words
The composition of claim 2 wherein said chealting agent is diethylene triamine pentaacetic acid.
Claim 6
Dependent Claim
17 words
The composition of any one of claims 1, 2, 3 or 4 wherein said protein is anti-myosin.
Claim 7
Dependent Claim
16 words
The composition of any one of claims 1, 2,3 or 4 wherein said protein is fibrinogen.
Claim 8
Dependent Claim
17 words
The composition of any one of claims 1, 2,3 or 4 wherein said protein is anti-carcinoembryonic antigen.
Claim 9
Dependent Claim
18 words
The composition of any one of claims 1, 2,3 or 4 wherein said protein is anti-alpha feto protein.
Claim 10
Dependent Claim
18 words
The composition of any one of claims 1, 2,3 or 4 wherein said protein is anti-human chorionic gonadotropin.
Claim 11
Dependent Claim
57 words
The process of forming the composition of claim 1 which comprises reducing an oxidized form of said radioactive molecule with dithionite ion to obtain a reduced form of said radioactive molecule and mixing said radioactive molecule with said proteing covalently linked to said chelating agent at a pH of at least about 7.0 up to about 9.0.
Claim 12
Dependent Claim
14 words
The process of claim 10 wherein said pH is between about 7.0 and 8.0
Claim 13
Dependent Claim
15 words
The process of claim 10 wherein the source of said dithionite ion is sodium dithionite.
Claim 14
Dependent Claim
14 words
The process of claim 11 wherein the source of said dithionite is sodium dithionite.
Claim 15
Dependent Claim
27 words
The process of any one of claims 11, 12 or 13 wherein the oxidized form of the radioactive'molecule is pertechnetate ion which is reduced to technetium-99m ion.
Claim 16
Dependent Claim
21 words
The process of any one of claims 11, 12 or 13 wherein the source of dithionite ion is particulate sodium dithionite.
References Cited (Backward Citations)
No citation records indexed.
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