EP0034049A1
Expired / Lapsed
EP
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Test device for analysis of a plurality of analytes
Assignee: Eastman Kodak Co
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Filing: 1981-02-05
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Granted: —
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Expires: 2001-02-05
Abstract
Abstract A test device and method are disclosed for the clinical analysis of liquids. Test device (10) comprises a plurality of test elements (30-36), each element being adapted to perform a separate analysis. All of the elements are supplied liquid from a single quantity of liquid, and the liquid is conveyed to the test elements through a liquid transport zone. To prevent contamination, control means are incorporated in test device (10) so that the liquid is confined to a plurality of flow paths, each of which extends to only one test element.
Inventors
- 👤 Richard Lewis Columbus
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 10:49
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
242 words
A test device for the analysis of a plurality of analytes in a liquid, said device comprising a support member and a cover member joined by an intermediate member, said cover and support members having opposed surfaces defining a liquid transport zone in which the surfaces are spaced apart a distance effective to induce capillary flow of said liquid, one of said members having access means for receiving and transporting a quantity of the liquid into said zone, said zone having therein a reagent composition for the generation of a detectable response indicative of an analyte characterized in that a plurality of individual test elements (30-36; 30a-36a; 30b-36b) are disposed in said zone (38; 38a; 38b) on one of said members (12, 14, 20; 12a, 14a, 20a; 12b, 14b, 20b) at locations spaced from each other and from said access means (46; 46a; 46b), one of said elements comprising said reagent composition and another of said elements comprising a reagent composition for the generation of a detectable response indicative of another analyte, and control means (20, 50; 20a, 50a; 50b, 70, 72) for confining liquid flow to a plurality of predetermined flow paths (52 I -52 IV ; 52b I -52b IV ) each of which extends from said access means (46; 46a; 46b) to only one of said test elements whereby the analytes in said quantity of liquid are detectable by the respective test elements without cross-contamination between the test elements.
Claim 2
Dependent Claim
242 words
A test device for the analysis of a plurality of analytes in a liquid, said device comprising a support member and a cover member joined by an intermediate member, said cover and support members having opposed surfaces defining a liquid transport zone in which the surfaces are spaced apart a distance effective to induce capillary flow of said liquid, one of said members having access means for receiving and transporting a quantity of the liquid into said zone, said zone having therein a reagent composition for the generation of a detectable response indicative of an analyte characterized in that a plurality of individual test elements (30-36; 30a-36a; 30b-36b) are disposed in said zone (38; 38a; 38b) on one of said members (12, 14, 20; 12a, 14a, 20a; 12b, 14b, 20b) at locations spaced from each other and from said access means (46; 46a; 46b), one of said elements comprising said reagent composition and another of said elements comprising a reagent composition for the generation of a detectable response indicative of another analyte, and control means (20, 50; 20a, 50a; 50b, 70, 72) for confining liquid flow to a plurality of predetermined flow paths (52 I -52 IV ; 52b I -52b IV ) each of which extends from said access means (46; 46a; 46b) to only one of said test elements whereby the analytes in said quantity of liquid are detectable by the respective test elements without cross-contamination between the test elements.
Claim 3
Dependent Claim
40 words
A device according to Claim 1, characterized in that said control means includes a vent means (50; 50a; 50b) associated with each of said test elements far venting air from said zone ahead of liquid flowing to the test element.
Claim 4
Dependent Claim
29 words
A device according to Claim 1 or 2, characterized in that said test elements each comprise an absorbent-layer (54, 56; 54a, 56a; 54b, 56b) containing at least one reagent.
Claim 5
Dependent Claim
30 words
A device according to Claim 1, 2 or 3, characterized in that each of said test elements includes all the reagents necessary for a radiometric assay of a particular analyte.
Claim 6
Dependent Claim
37 words
A device according to Claim 3, characterized in that said one element includes the reagents necessary for the detection of total protein and said other element includes the reagents necessary for the detection of blood urea nitrogen.
Claim 7
Independent Claim
23 words
A device according to any one of Claims 1 to 5, characterized in that said test elements are equidistant from said access means.
Claim 8
Independent Claim
23 words
A device according to any one of Claims 1 to 5, characterized in that said test elements are arranged in a side-by-side relationship.
Claim 9
Independent Claim
34 words
A device according to any one of Claims 1 to 5 and 7, characterized in that said control means includes a plurality of exposed grooves (70, 72) in at least one of said surfaces.
Claim 10
Dependent Claim
32 words
A device according to Claim 8, characterized in that said grooves (70, 72) are substantially linear and parallel and are orientated to confine the flow of liquid to said predetermined flow paths.
Claim 11
Dependent Claim
42 words
A device according to Claim 9, characterized in that both of said surfaces include a plurality of exposed grooves (70, 72), the grooves of one surface being orientated at a 90 degree angle with respect to the grooves of the other member.
Claim 12
Independent Claim
28 words
A device according to any one of the preceding Claims characterized in that one of said members (12, 14, 20; 12a, 14a, 20a; 12b, 14b, 20b) is transparent.
Claim 13
Independent Claim
97 words
A method of analyzing for a plurality of analytes in a liquid comprising the steps of depositing a quantity of the liquid into a receiving zone of a test device characterized by subjecting the liquid to capillary flow from the receiving zone along a plurality of separate flow paths in said device, each path extending to a single test element capable of reacting with a particular analyte to provide a detectable response whereby liquid is directed along each of said paths without cross-contamination between said test elements, and detecting said response at each of said test elements.
Claim 14
Independent Claim
97 words
A method of analyzing for a plurality of analytes in a liquid comprising the steps of depositing a quantity of the liquid into a receiving zone of a test device characterized by subjecting the liquid to capillary flow from the receiving zone along a plurality of separate flow paths in said device, each path extending to a single test element capable of reacting with a particular analyte to provide a detectable response whereby liquid is directed along each of said paths without cross-contamination between said test elements, and detecting said response at each of said test elements.
References Cited (Backward Citations)
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