EP0028937A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Albumin-fixed resin, process for its production, method of using it to remove noxious substances from solutions containing them, and its use in removing noxious substances from blood
Assignee: Teijin Ltd
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Filing: 1980-11-11
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Granted: —
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Expires: 2000-11-11
Abstract
Abstract The invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing 1 to 30 milliequivalents of amino groups and 1 to 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being bound ionically to the amino groups and by hydrogen bonding to the hydroxyl groups, and the amount of said albumin fixed being at least 25% by weight based on the epoxy resin. Also provided is a process for producing the albumin-fixed resin, which process comprises (1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule, and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said polyepoxy and polyamine compounds to addition reaction to produce an incompletely crosslinked pre-polymer, and then reacting the pre-polymer with at least one organic polyisocyanate, organic polyisothiocyanate or organic polycarboxylic acid halide to crosslink the pre-polymer fully, and (2) contacting the resulting crosslinked epoxy resin containing 1 to 30 milliequivalents of amino groups and 1 to 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albymin, optionally after partially neutralizing the amino groups of the epoxy resin. The albumin-fixed resin is useful for removing noxious substances capable of binding to albumin, such as bilirubin, from the blood of a warm-blooded animal.
Inventors
- 👤 Hideaki Suzuki
- 👤 Gentaro Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:28
CPC Classifications
C; C08; C08G; C08G81/00; A; A61; A61L; A61L33/00; A61L33/06; A61L33/068; A61M; A61M1/00; A61M1/36; A61M1/3687; B; B01; B01D; B01D15/00; B01D15/08; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/262; B01J20/265; B01J20/267; B01J20/28; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3221; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J20/3274; C08G18/00; C08G18/06; C08G18/28; C08G18/30; C08G18/32; C08G18/3225; C08G18/3228; C08G18/3246; C08G18/325; C08G18/40; C08G18/58; C08G18/584; C08G18/70; C08G18/72; C08G18/74; C08G18/76; C08G18/7657; C08G18/7664; C08G18/7671; C08L; C08L63/00; B01J2220/00; B01J2220/50; B01J2220/58
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
76 words
An albumin-fixed resin comprising a water-insoluble resin and albumin chemically bound thereto, characterised in that the water-insoluble resin is a crosslinked epoxy resin containing 1 to 30 milliequivalents of amino groups and 1 to 50 milliequivalents of hydroxyl groups per gram thereof, said albumin is bound ionically to the amino groups and by hydrogen bonding to the hydroxyl groups, and the amount of fixed albumin is at least 25% by weight based on the epoxy resin.
Claim 2
Dependent Claim
76 words
An albumin-fixed resin comprising a water-insoluble resin and albumin chemically bound thereto, characterised in that the water-insoluble resin is a crosslinked epoxy resin containing 1 to 30 milliequivalents of amino groups and 1 to 50 milliequivalents of hydroxyl groups per gram thereof, said albumin is bound ionically to the amino groups and by hydrogen bonding to the hydroxyl groups, and the amount of fixed albumin is at least 25% by weight based on the epoxy resin.
Claim 3
Dependent Claim
33 words
An albumin-fixed resin according to claim 1 characterised in that said crosslinked epoxy resin contains 2 to 20 milliequivalents of amino groups and 2 to 35 milliequivalents of hydroxyl groups per gram thereof.
Claim 4
Dependent Claim
33 words
An albumin-fixed resin according to claim 2 characterised in that the crosslinked epoxy resin contains 4 to 10 milliequivalents of amino groups and 4 to 25 milliequivalents of hydroxyl groups per gram thereof.
Claim 5
Dependent Claim
29 words
An albumin-fixed resin according to claim 1, 2 or 3, characterised in that the amount of fixed albumin is 25 to 150% by weight based on the epoxy resin.
Claim 6
Dependent Claim
28 words
An albumin-fixed resin according to any one of the preceding claims, characterised in that the crosslinked epoxy resin is derived from a polyepoxy compound and a polyamine compound.
Claim 7
Dependent Claim
51 words
An albumin-fixed resin according to any one of the preceding claims characterised in that the crosslinked epoxy resin is derived from an incompletely crosslinked pre-polymer obtained by reacting a polyepoxy compound with a polyamine compound, and at least one compound selected from organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides.
Claim 8
Dependent Claim
32 words
10 . A process according to claim 8 characterised in that at least one of glycerol triglycidyl ether, 1,1,1-trimethylolpropane triglycidyl ether, phloroglucinol triglycidyl ether and triglycidyl isocyanurate is used as triglycidyl ether.
Claim 9
Dependent Claim
97 words
A process according to any one of claims 7 to 10, characterised in that an aliphatic diamine, an alicyclic diamine, an aromatic diamine, or a polyalkylenepolyamine of the formula wherein R 1 and R 2 are identical or different, and each represents a hydrogen atom, or an alkyl, alkenyl, hydroxyalkyl, aryl or aralkyl group, R 3 represents a hydrogen atom or a beta-aminoethyl group, and p is a number of 2 to 10, provided that two or more R 3 groups, independently from each other, are hydrogen atoms or beta-aminoethyl groups is used as the polyamine compound.
Claim 10
Dependent Claim
37 words
1 2 . A process according to claim 11 characterised in that a compound of the formula wherein q is an integer of 2 to 10, or a compound of the formula is used as alicyclic diamine.
Claim 11
Dependent Claim
22 words
A process according to claim 11 characterised in that piperazine, 2,5-dimethylpiperazine or diamino- cyclohexane of the formula is used as alicyclic diamine.
Claim 12
Dependent Claim
149 words
A process for producing an albumin-fixed resin as claimed in claim 1, which process comprises. (1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/o r secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said polyepoxy and polyamine compounds to addition reaction to produce an incompletely crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from organic polyisocyanates, organic polyisothiocyanates and organic poly- polycarboxylic acid halides to crosslink the pre-polymer fully, and (2) contacting the resulting crosslinked epoxy resin containing 1 to 30 milliequivalents of amino groups and 1 to 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin, optionally after partially neutralizing the amino groups of the epoxy resin.
Claim 13
Dependent Claim
20 words
A process according to claim 7 characterised in that a di- or tri-glycidyl ether is used as the polyepoxy compound.
Claim 14
Dependent Claim
60 words
A process according to claim 8 characterised in that at least one of a compound of the formula wherein n is a number of 2 to 10, a compound of the formula wherein m is a number of 2 to 10, glycerol diglycidyl ether, bisphenol A diglycidyl ether, hydroquinone diglycidyl ether and resorcinol diglycidyl ether is used as the diglycidylether%
Claim 15
Dependent Claim
40 words
A process according to claim 11 characterised in that a diaminobenzene of the formula or a diaminobisphenylene compound of the formula wherein X represents a bond, ammethylene group, a dimethylmethylene group, or an oxygen atom is used as aromatic diamine.
Claim 16
Dependent Claim
45 words
A process according to any one of claims 7 to 14, characterised in that step (1), (a) is performed using 0.8 to 2.0 equivalents of the epoxy groups of the polyepoxy compound per equivalent of the primary and/or secondary amino groups of the polyamine compound.
Claim 17
Dependent Claim
46 words
A process according to any one of claims 7 to 14 characterised in that step (1), (b) is carried out using 0.5 to 2.0 equivalents of the epoxy groups of the polyepoxy compound per equivament of the primary and/or secondary amino groups of the polyamine compound.
Claim 18
Dependent Claim
60 words
A process according to any one of claims 7 to 16, characterised in that the addition reaction of the polyepoxy compound and the polyamine compound is carried out by dispersing in an aqueous medium in the optional presence of a dispersant a solution of the polyepoxy compound and the polyamine compound in a water-insoluble or sparingly water-soluble inert organic solvent.
Claim 19
Independent Claim
54 words
A method for removing noxious substances capable of binding to albumin from a solution containing them, which method comprises contacting an albumin-fixed resin as claimed in any one of claims 1 to 6 intimately with a solution of at least one such noxious substance to be found in the blood of a warm-blooded animal.
Claim 20
Independent Claim
98 words
A method for removing a noxious substance capable of binding to albumin from the blood of a warm-blooded animal, which method comprises extracorporeally drawing the blood of a warm-blooded animal from which it is desired to remove said noxious substance, contacting an albumin-fixed resin as claimed in any one of claims lto 6 intimately with the blood, the plasma separated therefrom, or a dilution of the blood or plasma with a blood isotonic solution, and therafter returning to the body of the animal the blood, plasma or the dilution thereof from which the noxious substance has been removed.
Claim 21
Dependent Claim
24 words
A method according to claim 19 characterised in that the albumin-binding noxious substance is bilirubin, and the animal is a human with hepatic failure.
Claim 22
Dependent Claim
34 words
Use of an albumin-fixed resin as claimed in any one of claims 1 to 6 in the removal from the blood of a warm-blooded animal of a noxious substance capable of binding to albumin.
References Cited (Backward Citations)
No citation records indexed.
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