Patent US2784851A successfully refreshed from Google Patents.
EP0017355A2
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EP
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Indium-111 oxine complex composition
Assignee: GE Healthcare Ltd
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Filing: 1980-03-11
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Granted: —
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Expires: 2000-03-11
Abstract
Abstract An indium-111 preparation comprises a complex of indium-111 with a quinoline compound carrying an 8-hydroxyl group, e.g. oxine, present in an aqueous medium which also contains a surface active agent to prevent the complex from becoming bound to the surface of the vessel on autoclaving, and optionally a buffer to improve blood cell labelling efficiency. The surface active agent is preferably non-ionic, e.g. a polyoxyethylene sorbitan ester of a fatty acid. The buffer is preferably N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid.
Inventors
- 👤 James Duncan Kelly
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 09:33
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1203; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
37 words
An indium-111 preparation comprising a complex of indium-111 with a quinoline compound carrying a hydroxyl group in the 8- position, present in an aqueous medium which also contains at least 10 µg/ml of a surface active agent.
Claim 2
Dependent Claim
37 words
An indium-111 preparation comprising a complex of indium-111 with a quinoline compound carrying a hydroxyl group in the 8- position, present in an aqueous medium which also contains at least 10 µg/ml of a surface active agent.
Claim 3
Dependent Claim
13 words
A preparation as claimed in claim 1 wherein the quinoline compound is 8-hydroxyquinoline.
Claim 4
Dependent Claim
21 words
A preparation as claimed in claim 1 or claim 2 wherein the surface active agent is a non-ionic surface active agent.
Claim 5
Dependent Claim
26 words
A preparation as claimed in any one of claims 1 to 3, wherein the surface active agent is selected from polyoxyethylene sorbitan esters of fatty acids.
Claim 6
Dependent Claim
27 words
A preparation as claimed in any one of claims 1 to 4, wherein the concentration of the surface active agent is from 10 µg/ml to 1000 µg/ml.
Claim 7
Dependent Claim
38 words
A preparation as claimed in any one of claims 1 to 5, wherein the concentration of indium-111 is from 0.1 to 10 mCi/ml and the concentration of the quinoline compound is from 5 to 100 µg/mCi of indium-111.
Claim 8
Dependent Claim
31 words
A preparation as claimed in any one of claims 1 to 6, wherein there is also present a non-toxic compatible buffer to maintain the pH in the range 5 to 8.
Claim 9
Dependent Claim
13 words
A preparation as claimed in claim 7, wherein the buffer is N-2-hydroxy-ethylpiperazine-N'-2-ethanesulphonic acid.
Claim 10
Dependent Claim
21 words
A preparation as claimed in claim 7 or claim 8, wherein the concentration of the buffer is from 0.02M to 0.5M.
References Cited (Backward Citations)
No citation records indexed.
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