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EP0013566A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Method for providing enteric coating on solid dosage forms

Assignee: Shin-Etsu Chemical Co Ltd
•
Filing: 1980-01-08
•
Granted: —
•
Expires: 2000-01-08
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Abstract

Abstract The invention provides a novel method for providing entric coating on solid dosage forms using an aqueous coating liquid so thatthe problems inherent to the use of a coating liquid in an organic solvent can completely be eliminated. The inventive method comprises dispersing a finely divided powder of a hydroxypropylmethylcellulose phthalate in an aqueous medium containing triacetin to give an aqueous coating liquid with which the solid dosage forms are coated, for example, by spraying and dried. It is necessary that the preparation of the coating liquid and the coating procedure with the coating liquid are performed throughout while keeping the temperature of the liquid below 25°C so as that the particles of the hydroxypropylmethycellulose phthalate are not dissolved in the medium forming a stable dispersion without adhesive coalescence.

Inventors

  • 👤 Tonedachi Masayuki
  • 👤 Sekigawa Fujio
  • 👤 Minemura Katsuyoshi

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 16:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4891; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 88 words
A method for providing enteric coating on a solid dosage form which comprises (a) dispersing a hydroxypropylmethylcellulose phthalate having an average particle diameter not exceeding 100 µm in water containing triacetin at a temperature of 25°C orbelow to form an aqueous coating liquid, (b) spraying the thus prepared coating liquid on to the surface of the solid dosage form while the coating liquid is kept at a temperature of 25 C or below to form a coating layer thereon, and (c) drying the thus coated solid dosage form.
Claim 2
Independent Claim 88 words
A method for providing enteric coating on a solid dosage form which comprises (a) dispersing a hydroxypropylmethylcellulose phthalate having an average particle diameter not exceeding 100 µm in water containing triacetin at a temperature of 25°C orbelow to form an aqueous coating liquid, (b) spraying the thus prepared coating liquid on to the surface of the solid dosage form while the coating liquid is kept at a temperature of 25 C or below to form a coating layer thereon, and (c) drying the thus coated solid dosage form.
Claim 3
Dependent Claim 46 words
The method for providing enteric coating on a solid dosage form as claimed in claim 1 wherein the amount of triacetin in the aqueous coating liquid is in the range from 5 % to 50 % by weight based on the amount of the hydroxypropylmethylcellulose phthalate.
Claim 4
Dependent Claim 33 words
The method for providing enteric coating on a solid dosage form as claimed in claim 1 wherein the thickness of the coating film is in the range from 0.01 mm to 0.20 mm.
Claim 5
Dependent Claim 34 words
The method for providing enteric coating on a solid dosage form as claimed in claim 1 wherein the solid dosage form is provided with an undercoating prior to the step (b) in claim 1.
Claim 6
Dependent Claim 24 words
The method for providing enteric coating on a solid dosage form as claimed in claim 4 wherein the undercoating is provided with a hydroxypropylmethylcellulose.

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