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CA1076752A Expired / Lapsed CA ⏱️ 0.0 years remaining

Arteries for use in heterologous transplants

Assignee: ICN Switzerland AG
•
Filing: 1975-11-10
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Granted: 1980-05-06
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Expires: 1995-11-10
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Abstract

Abstract ABSTRACT OF THE DISCLOSURE The invention relates to a new process for the preparation of arteries for use in heterologous transplants which reduces immunological drawbacks and decreases the risk of contamination and/or infection. The process comprises obtaining a length of animal artery free from surrounding tissue, any collateral vessels being sealed off, removing muscle tissue and elastic fibres from the wall of the artery by proteolytic splitting whereby a solution containing a proteolytic enzyme at an appropriate pH is passed continuously through the artery and subjecting the collagen tube thereby produced to tanning by passing continuously therethrough a buffered cross-linking solution whereby the density and stability of the tube is increased.

Inventors

  • 👤 Heribert Schmitz
  • 👤 Walter Stocklin

Bibliographic Details

Application Number —
Jurisdiction CA
Data Source google_patents
Last Synchronized 2026-10-23 03:20
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3625; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61L27/50; A61L27/507; A61L2430/00; A61L2430/40; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 89 words
A process for the preparation of arteries for use in heterologous transplants which comprises obtaining a length of animal artery free from surrounding tissue, any collateral vessels being sealed off, removing muscle tissue and elastic fibres from the wall of the artery by proteolytic splitting whereby a solution containing a proteolytic enzyme at an appropriate pH is passed continuously through the artery and subjecting the collagen tube there-by produced to tanning by passing continuously therethrough a buffered cross-linking solution whereby the density and stability of the tube is increased.
Claim 2
Dependent Claim 89 words
A process for the preparation of arteries for use in heterologous transplants which comprises obtaining a length of animal artery free from surrounding tissue, any collateral vessels being sealed off, removing muscle tissue and elastic fibres from the wall of the artery by proteolytic splitting whereby a solution containing a proteolytic enzyme at an appropriate pH is passed continuously through the artery and subjecting the collagen tube there-by produced to tanning by passing continuously therethrough a buffered cross-linking solution whereby the density and stability of the tube is increased.
Claim 3
Dependent Claim 15 words
A process as claimed in claim 1 wherein the animal artery is a caro-tid artery.
Claim 4
Dependent Claim 20 words
A process as claimed in claim 1 or claim 2 wherein the artery is of bovine, ovine or porcine origin.
Claim 5
Dependent Claim 16 words
A process as claimed in claim 1 wherein the artery is obtained from a young animal.
Claim 6
Dependent Claim 20 words
A process as claimed in claim 1, 2 or 3 wherein the artery is ob-tained from a new born animal.
Claim 7
Dependent Claim 16 words
A process as claimed in claim 1 wherein the proteolytic enzyme is ficin, trypsin or papain.
Claim 8
Dependent Claim 21 words
A process as claimed in claim 1 wherein the tanning solution con-tains dialdehyde starch, glyoxal, polyacroleine, formaldehyde, dialdehyde cellulose or glutaraldehyde.
Claim 9
Dependent Claim 35 words
A process as claimed in claim 1 wherein the collagen tube is tanned whereby the density and stability are increased such that the tube is able to withstand a pressure equivalent to 240 mm Hg.
Claim 10
Dependent Claim 18 words
A process as claimed in claim 1 wherein the collateral vessels are sealed by being tied with silk.

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